DR. HIROAKI KITAGISHI

Professor

Department of Molecular Chemistry and Biochemistry
Doshisha University, Kyoto, Japan

twitter

EDUCATION:

March 2001: Bachelor of Engineering, Doshisha University

March 2003: Master of Engineering, Nara Institute Science & Technology

Supervisor: Prof. Yoshiaki Kobuke

March 2006: Doctor of Engineering, Doshisha University

Supervisor: Prof. Koji Kano

PROFESSIONAL EXPERIENCE:

April 2006

– March 2008: Postdoctoral Fellow at Osaka University

Collaborator: Prof. Takashi Hayashi

April 2008

– March 2014: Assistant Professor at Doshisha University

Collaborator: Prof. Koji Kano

Sept. 2009

– August 2010: Guest Researcher at The Scripps Research

Institute

Collaborator: Prof. M. G. Finn

April 2014

– March 2020: Associate Professor at Doshisha University

April 2020

– Present: Professor at Doshisha Univeristy

RESEARCH FIELD:

Supramolecular Chemistry, Organic Chemistry, Bioinorganic Chemistry, Biological Chemistry

PUBLICATION LIST

A. Nakagami, Q. Mao, M. Horitani, M. Kodera, H. Kitagishi
“Detoxification of hydrogen sulfide by synthetic heme model compounds”
Sci Rep, 14, 29371 (2024).
(DOI: https://doi.org/10.1038/s41598-024-80511-1)
Q. Mao, A. Nakagami, M. Kodera, H. Kitagishi
“The strategy of using heme proteins and synthetic porphyrins as injectable antidotes for fire gas poisoning”
Chemistry Letters, 53, 11, upae203 (2024).
(DOI: https://doi.org/10.1093/chemle/upae203)
X. Chen, J. Liu, M. Chen, J. Zhou, Y. Zhang, X. Hu, W. Geng, Q. Mao, H. Kitagishi, J. Chen, X. Qian, Y. Yang, Y. Lei, X. Luo
“Green-Light-Triggered and Self-Calibrated Cascade Release of Nitric Oxide and Carbon Monoxide for Synergistic Glaucoma Therapy”
J. Am. Chem. Soc., 146, 44, 30361–30371 (2024).
(DOI: https://pubs.acs.org/doi/10.1021/jacs.4c10457)
K. Watanabe, Y. Uetake, M. Hata, A. Kuwano, R. Yamamoto, Y. Yamamoto, M. Kodera, H. Kitagishi, T. Niwa, T. Hosoya
“Red‐light Emitting Orthogonally Trireactive Gold Nanoclusters for the Synthesis of Multifunctionalized Nanomaterials”
Small, 2408747 (2024).
(DOI: https://doi.org/10.1002/smll.202408747)
K. A. Nguyen, A. Matte, R. Foresti, E. Federti, L. Kiger, C. Lefebvre, H. Hocini, Y. Pelinski, H. Kitagishi, L. Bencheikh, F. Pirenne, L. de Franceschi, R. Motterlini, P. Bartolucci
“An oral carbon monoxide–releasing molecule protects against acute hyperhemolysis in sickle cell disease”
Blood, 143, 2544–2558 (2024).
(DOI: https://doi.org/10.1182/blood.2023023165 )
H. Yanagisawa, H. Maeda, I. Noguchi, M. Tanaka, N. Wada, T. Nagasaki, K. Kobayashi, G. Kanazawa, K. Taguchi, V. T. G. Chuang, H. Sakai, H. Nakashima, M. Kinoshita, H. Kitagishi, Y. Iwakiri, Y.Sasaki, Y.Tanaka, M. Otagiri, H. Watanabe, T. Maruyama
“Carbon monoxide-loaded red blood cells ameliorate metabolic dysfunction-associated steatohepatitis progression via enhancing AMP-activated protein kinase activity and inhibiting Kupffer cell activation”
Redox Biology, 76, 103314 (2024).
(DOI: https://doi.org/10.1016/j.redox.2024.103314)
K. Asai, Q. Mao, A. Nakagami, H. Kitagishi
“Cyclodextrin-Based Catenanes Platformed with meso-Arylporphyrin”
European Journal of Organic Chemistry, 27, e202400081 (2024).
(DOI: https://doi.org/10.1002/ejoc.202400081)
A. T. Kawaguchi, T. Tanaka, M. Yamano, H. Sumiyoshi, H. Kitagishi, Y. Yamada, G. T. Kawaguchi, J. Bergsland
“Carboxyhemoglobin Particle Infusion, but not Carbon Monoxide Inhalation ameliorates Myocardial Infarction via Attenuated Oxidative Stress and In Situ Inflammation in a Rat Model”
Medical Research Archives, 11, 11 (2023).
(DOI: https://doi.org/10.18103/mra.v11i11.4810 )
K. Watanabe, Q. Mao, Z. Zhang, M. Hata, M. Kodera, H. Kitagishi, T. Niwa, T. Hosoya
“Clickable bisreactive small gold nanoclusters for preparing multifunctionalized nanomaterials: application to photouncaging of an anticancer molecule”
Chemical Science, 15, 1402–1408 (2024).
(DOI: https://pubs.rsc.org/en/content/articlehtml/2024/sc/d3sc04365g)
D. E. Benrahla, S. Mohan, M. Trickovic, F. A. Castelli, G. Alloul, A. Sobngwi, R. Abdiche, S. Kieser, V. Demontant, E. Trawinski, C. Chollet, C. Rodriguez, H. Kitagishi, F. Fenaille, M. Trajkovski, R. Motterlini, R. Foresti
“An orally active carbon monoxide-releasing molecule enhances beneficial gut microbial species to combat obesity in mice”
Redox Biology, 72, 103153 (2024).
(DOI: https://www.sciencedirect.com/science/article/pii/S2213231724001290)
M. Noguchi, Q. Mao, A. Nakagami, H. Kitagishi
“Spontaneous reduction of iron(iii)porphyrin to iron(ii)porphyrin–CO complex in mouse circulation”
Chemical Communications, 59, 6211–6214 (2023).
https://pubs.rsc.org/en/content/articlelanding/2023/cc/d3cc00420a

S. Mohan, L.-A. Barel, D. E. Benrahla, B. Do, Q. Mao, H. Kitagishi, M. Rivard, R. Motterlini, R. Foresti
“Development of carbon monoxide-releasing molecules conjugated to polysaccharides (glyco-CORMs) for delivering CO during obesity”
Pharmacological Research, 191, 106770 (2023).
(DOI: https://doi.org/10.1016/j.phrs.2023.106770)
Q. Mao, H. Kitagishi
“Inclusion Complex Formation with Tetra-PEGylated Tetraphenylporphyrin and Face-to-Face Cyclodextrin Dimer through Unprecedented Molecular Threading”
Chemistry–A European Journal, e202300408 (2023).
(DOI: https://doi.org/10.1002/chem.202300408)
Q. Mao, X. Zhao, A. Kiriyama, S. Negi, Y. Fukuda, H. Yoshioka, A. T. Kawaguchi, R. Motterlini, R. Foresti, H. Kitagishi
“A synthetic porphyrin as an effective dual antidote against carbon monoxide and cyanide poisoning”
Proceedings of the National Academy of Sciences, 120, e2209924120 (2023).
(DOI: 10.1073/pnas.2209924120 )
S. Negi, M. Hamori, Y. Kawahara-Nakagawa, M. Mashimo, M. Imanishi, N. Kuki, Y. Kawahito, T. Manabe, N. Kawamura, J. Yasukawa, H. Kitagishi, Y. Sugiura
“Effect of Charged-cluster Distribution of the ZIF268 Zinc Finger Surface on Cell Membrane Permeability”
Chemistry Letters, 52, 75–78 (2023).
(DOI: https://doi.org/10.1246/cl.220464)
S. Negi, M. Hamori, Y. Kubo, H. Kitagishi, K. Kano
“Monolayer formation and chiral recognition of binaphthyl amphiphiles at the air–water interface”
Bulletin of the Chemical Society of Japan, 96, 48–56 (2023).
(DOI: 10.1246/bcsj.20220286)
S. Negi, M. Hamori, H. Kitagishi, K. Kano
“Highly Ordered Monolayers of an Optically Active Amphiphilic Pyrene Derivative at the Air–Water Interface”
Bulletin of the Chemical Society of Japan, 95, 1537–1545 (2022).
(DOI: 10.1246/bcsj.20220233)
M. Tang, Y.-H. Liu, H. Liu, Q. Mao, Q. Yu, H. Kitagishi, Y.-M. Zhang, L. Xiao, Yu Liu
“Supramolecular Dual Polypeptides Induced Tubulin Aggregation for Synergistic Cancer Theranostics”
Journal of Medicinal Chemistry, 65, 13473-13481 (2022).
(DOI: 10.1021/acs.jmedchem.2c01398)
H. Kitagishi, I. Sagami
“Role of CO in Circadian Clock”
In Carbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential, (Chapter 5, pp 97–107, 2022).
(DOI: https://doi.org/10.1002/9781119783435.ch5)
S. Negi, M. Hamori, A. Sato, K. Shimizu, Y. Kawahara-Nakagawa, T. Manabe, N. Shibata, H. Kitagishi, M. Mashimo, Y. Sugiura
“Transpeptidation Reaction Mediated by Ligand- and Metal Cofactor-Substituted Sortase A from Staphylococcus aureus”
Bulletin of the Chemical Society of Japan, 95, 1025–1031 (2022).
(DOI: 10.1246/bcsj.20220098)
S. Negi, M. Hamori, Y. Kawahara-Nakagawa, M. Imanishi, M. Kurehara, C. Kitada, Y. Kawahito, K. Kishi, T. Manabe, N. Kawamura, H. Kitagishi, M. Mashimo, N. Shibata, Y. Sugiura
“Importance of two-dimensional cation clusters induced by protein folding in intrinsic intracellular membrane permeability”
RSC Chemical Biology, 3, 1076–1084 (2022).
https://pubs.rsc.org/en/content/articlehtml/2022/cb/d2cb00098a
R. Tachikawa, H. Saito, H. Moteki, M. Kimura, H. Kitagishi, F. Arce Jr., G. L. See, T. Tanikawa, Y. Inoue
“Preparation, Characterization, and In Vitro Evaluation of Inclusion Complexes Formed between S-Allylcycteine and Cyclodextrin”
ACS Omega, 7, 31233–31245 (2022).
(DOI: 10.1021/acsomega.2c03489)

T. Nagasaki, H. Maeda, K. Taguchi, H. Yanagisawa, K. Nishida, K. Kobayashi, N. Wada, I.Noguchi, R. Murata, H. Sakai, H. Kitagishi,J. Saruwatari, H. Watanabe,M. Otagiri, T. Maruyama
“A Bioinspired Carbon Monoxide Delivery System Prevents Acute Kidney Injury and the Progression to Chronic Kidney Disease”
Redox Biology, 54, 102371 (16 pages) (2022).
(DOI: 10.1016/j.redox.2022.102371)
H. Kitagishi, Q. Mao
“Capture of carbon monoxide using a heme protein model: from biomimetic chemistry of heme proteins to physiological and therapeutic applications”
Polymer Journal, 54, 465-472 (2022).
(DOI: 10.1038/s41428-021-00591-y)
A. Nakagami, Q. Mao, G. Gouhier, H. Arima, H. Kitagishi
“FRET-Based In-Cell Detection of Highly Selective Supramolecular Complexes of meso-Tetraarylporphyrin with Peptide/BODIPY-modified Per-O-methyl-β-cyclodextrins”
ChemBioChem, 16, 3190-3198 (2021)..
(DOI: 10.1002/cbic.202100380)
Q. Mao, P. K. Das, S. Le Gac, B. Boitrel, V. Dorcet, K. Oohora, T. Hayashi, H. Kitagishi
“Functional Myoglobin Model Composed of a Strapped Porphyrin/Cyclodextrin Supramolecular Complex with an Overhanging COOH That Increases O2/CO Binding Selectivity in Aqueous Solution”
Inorganic Chemistry, 60, 12392–12404 (2021)..
(DOI: 10.1021/acs.inorgchem.1c01628)
Q. Mao, A. T. Kawaguchi, S. Mizobata, R. Motterlini, R. Foresti, H. Kitagishi
“Sensitive quantification of carbon monoxide (CO) in vivo reveals a protective role of circulating hemoglobin in CO intoxication”
Communications Biology, 4, 425 (2021) (15 pages).
https://www.nature.com/articles/s42003-021-01880-1

H. Kitagishi, K. Kano
“Synthetic heme protein models that function in aqueous solution”
Chemical Communications, 57, 148–173 (2021)..
(DOI: 10.1039/D0CC07044K)
H. Kitagishi, M. Jiromaru, N. Hasegawa

“Intracellular Delivery of Adamantane-tagged Small Molecule, Proteins, and Liposomes Using an Octaarginine-conjugated β-Cyclodextrin”

ACS Applied Bio Materials, 3, 4902–4911 (2020).

(DOI: 10.1021/acsabm.0c00421)
K. Ueno, J. Morstein, K. Ofusa, S. Naganos, E. Suzuki-Sawano, S. Minegishi, S. P. Rezgui, H. Kitagishi, B. W. Michel, C. J. Chang, J. Horiuchi, M. Saitoe

“Carbon Monoxide, a Retrograde Messenger Generated in Postsynaptic Mushroom Body Neurons, Evokes Noncanonical Dopamin Release”

Journal of Neuroscience, 40, 3533–3548 (2020).

(DOI: 10.1523/JNEUROSCI.2378-19.2020)
R. Nishiyabu, Y. Takahashi, T. Yabuki, S. Gommori, Y. Yamamoto, H. Kitagishi, Y. Kubo

“Boronate Sol-Gel Method for One-Step Fabrication of Polyvinyl Alcohol Hydrogel Coating by Simple Cast- and Dip-Coating Techniques”

RSC Advances, published on web (2020).

(DOI: 10.1039/C9RA08208E)
H. Kitagishi

“In Vivo Reactions Triggered by Selective Removal of Endogenous Carbon Monoxide in Blood Using an Artificial Hemoprotein Model Complex”

Artificial Blood, 27, 44–52 (2019) (written in Japanese).

(https://www.blood-sub.jp/kaisinituite.php)
M. Vonesch, J. A. Wytko, H. Kitagishi, K. Kano, J. Weiss

“Modeling Haemoproteins: Porphyrins and Cyclodextrins as Sources of Inspiration”

Chemical Communications, 27, 44–52 (2019).

(DOI: 10.1039/C9CC07545C)
H. Kitagishi, M. Saito, Q. Mao, A. Kiriyama, S. Negi, K. Kano

“Supramolecular Complexation in Biological Media. NMR Study on Inclusion of an Anionic Tetraarylporphyrin into a Heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin Cavity in Serum, Blood, and Urine”

Chemistry–An Asian Journal, 14, 3320–3328 (2019).

(DOI:10.1002/asia.20190983)
H. Kitagishi, K. Ohara, D. Shimoji, M. Vonesch, J. Weiss, J. A. Wytko

“Hydrogen Bond Directed Molecular Recognition in Water in a Strapped-Porphyrin-Cyclodextrin Assembly”

Journal of Porphyrins and Phthalocyanines, 23, 569–574 (2019).

(DOI:10.1142/S1088424619500494)
R. Suzuki, Y. Inoue, I. Murata, H. Nomura, Y. Issiki, M. Hashimoto, Y. Kudo, H. Kitagishi, S. Kondo, I. Kanamoto

“Preparation, Characterization, and Study of the Antimicrobial Activity of a Hinokitiol-copper(II)/γ-cyclodextrin Ternary Complex”

Journal of Molecular Structure, 1194, 9–27 (2019).

(DOI:10.1016/j.molstruc.2019.05.078)
M. Kodera, Y. Kadoya, K. Aso, K. Fukui, A. Nomura, Y. Hitomi, H. Kitagishi

“Acceleration of Hydrolytic DNA Cleavage by Dicopper(II) Complexes with p-Cresol-Derived Dinulearing Ligands at Slightly Acidic pH and Mechanistic Insights”

Bulletin of the Chemical Society of Japan, 92, 739–747 (2019).

(DOI:10.1246/bcsj.20180353)
A. Ollivier, R. Foresti, Z. El Ali, T. Martens, H. Kitagishi, R. Motterlini, M. Rivard

“Design and Biological Evaluation of Manganese- and Ruthenium-based Hybrid CO-RMs (HYCOs)”

ChemMedChem, 14, 1684–1691 (2019).

(DOI:10.1002/cmdc.201900426)
K. Oohora, R. Kajihara, M. Jiromaru, H. Kitagishi, T. Hayashi

“Arginine Residues Provide a Multivalent Effect for Cellular Uptake of a Hemoprotein Assembly”

Chemistry Letters, 48, 295–298 (2019).

(DOI:10.1246/cl.180897)
Q. Mao, H. Kitagishi

“Optimized Synthesis of a Per-O-methylated β-Cyclodextrin Dimer Linked at the Secondary Face by a Pyridine Ligand”

Journal of Inclusion Phenomena and Macrocyclic Chemistry, 93, 67–76 (2019).

(DOI:10.1007/s10847-018-0839-4)
L. Braud, M. Pini, L. Muchova, S. Manin, H. Kitagishi, D. Sawaki, G. Czibik, J. Ternacle, G. Derumeaux, R. Foresti, R. Motterlini

“Carbon Monoxide-induced Metabolic Switch in Adipocytes Improves Insulin Resistance in Obese Mice”

JCI Insight, 3, e123485 (2018).

(DOI:10.1172/jci.insight.123485)
A. T. Kawaguchi, A. Salybekov, M. Yamano, H. Kitagishi, K. Sekine

“PEGylated Carboxyhemoglobin Bovine (SUNGUINATE) Ameliorates Myocardial Infatction in a Rat Model”

Artificial Organs, 42, 1174–1184 (2018).

(DOI:10.1111/aor.13384)
S. Minegishi, I. Sagami, S. Negi, K. Kano, H. Kitagishi

“Circadian Clock Disruption by Selective Removal of Endogenous Carbon Monoxide”

Scientific Reports, 8, 11996 (2018).

(DOI: 10.1038/s41598-018-30425-6)
H. Kitagishi, D. Shimoji, T. Ohta, R. Kamiya, Y. Kudo, A. Onoda, T. Hayashi, J. Weiss, J. A. Wytko, K. Kano

“A Water-Soluble Supramolecular Complex that Mimics the Heme/Copper Hetero-Binuclear Site of Cytochrome c Oxidase”

Chemical Science, 9, 1989–1995 (2018).(DOI: 10.1039/C7SC04732K)
S. Minegishi, A. Yumura, H. Miyoshi, S. Negi, S. Taketani, R. Motterlini, R. Foresti, K. Kano, H. Kitagishi

“Detection and Removal of Endogenous Carbon Monoxide by Selective and Cell-permeable Hemoprotein-model Complexes”

Journal of the American Chemical Society, 139, 5984–5991 (2017).

(DOI: 10.1021/jacs.7b02229)
H. Kitagishi, S. Minegishi

“Iron(II)porphyrin–Cyclodextrin Supramolecular Complex as a Carbon Monoxide-Depleting Agent in Living Organisms

Chemical and Pharmaceutical Bulletin, 65, 336–340 (2017).

(DOI:10.1248/cpb.c16-00767)
H. Kitagishi, Y. Sugaya, K. Komazawa, M. Tamaki, K. Kano

“Participation of Hydroxyl Radical in the Formation of Verdoheme-type Compound in the Reaction of a Ferric Porphyrin with Hydrogen Peroxide”

Chemistry Letters, 46, 509–512 (2017).

(DOI:10.1246/cl.161161)
H. Kitagishi, Q. Mao, N. Kitamura, T. Kita

“HemoCD as a Totally Synthetic Artificial Oxygen Carrier: Improvements in the Synthesis and O2/CO Discrimination”

Artificial Organs, 41, 372–380 (2017).

(DOI:10.1111/aor.12870)
R. Nishiyabu, S. Iizuka, S. Minegishi, H. Kitagishi, Y. Kubo

“Surface Modification of a Polyvinyl Alcohol Sponge with Functionalized Boronic Acids to Develop Porous Materials for Multicolor Emission, Chemical Sensing and 3D Cell Culture”

Chemical Communications, 53, 3563–3566 (2017).

(DOI:10.1039/c7cc00490g)
H. Kitagishi, S. Kurosawa, K. Kano

“Intramolecular Oxidative O-Demethylation of an Oxoferryl Porphyrin Complexed with a Per-O-methylated β-Cyclodextrin Dimer”

Chemistry –An Asian Jouranl, 11, 3213–3219 (2016).

(DOI: 10.1002/asia.201601097)
W. Takabe, Y. Urano, D. H. Vo, K. Shibuya, M. Tanno, H. Kitagishi, T. Fujimoto, N. Noguchi

“Esterification of 24S-OHC Induces Formation of Atypical Lipid Droplet-like Structures, Leading to Neuronal Cell Death”

Journal of Lipid Research, 57, 2005–2014 (2016).

(DOI: 10.1194/jlr.M068775)
K. Shibuya, T. Watanabe, Y. Urano, W. Takabe, N. Noguchi, H. Kitagishi

“Synthesis of 24(S)-Hydroxycholesterol Esters Responsible for the Induction of Neuronal Cell Death”

Bioorganic & Medicinal Chemisty, 24, 2559–2566 (2016).

(DOI: 10.1016/j.bmc.2016.04.024)
H. Kitagishi, S. Minegishi, A. Yumura, S. Negi, S. Taketani, Y. Amagase, Y. Mizukawa, T. Urushidani, Y. Sugiura, K. Kano

“Feedback Response to Selective Depletion of Endogenous Carbon Monozide in the Blood”

Journal of the American Chemical Society, 138, 5417–5425 (2016).

(DOI: 10.1021/jacs.6b02211)
K. Imabeppu, H. Kuwano, E. Yutani, H. Kitaghishi, K. Kano

“Photoinduced Homolysis of Alkyl-Cobalt(III) Bonds in a Cyclodextrin Cage”

European Journal of Inorganic Chemistry, 1784–1789 (2016).

(DOI: 10.1002/ejic.201600208)
H. Kitagishi, H. Kawasaki, K. Kano

“Bioconjugation of Serum Albumin to a Maleimide-appended Porphyrin/Cyclodextrin Supramolecular Complex as an Artificial Oxygen Carrier in the Bloodstream”

Chemistry –An Asian Journal, 10, 1768–1775 (2015).

(DOI: 10.1002/asia.201500451)
K. Watanabe, T. Suzuki, H. Kitagishi, K. Kano

“Reaction Between a Haemoglobin Model Compound and Hydrosulphide in Aqueous Solution”

Chemical Communications, 51, 4059–4061 (2015).

(DOI: 10.1039/C5CC00057B)
H. Kitagishi, F. Chai, S. Negi, Y. Sugiura, K. Kano

“Supramolecular Intracellular Delivery of an Anionic Porphyrin by Octaarginine-conjugated Per-O-methyl-β-Cyclodextrin”

Chemical Communications, 51, 2421–2424 (2015).

(DOI: 10.1039/C4CC09042J)
T. Ueda, H. Kitagishi, K. Kano

“Intramolecular Direct Oxygen Transfer from Oxoferryl porphyrin to a Sulfide Bond”

Inorganic Chemistry, 53, 543–551 (2014).

(DOI: 10.1021/ic4026393)
T. Yamagiwa, A. T. Kawaguchi, T. Saito, S. Inoue, S. Morita, K. Watanabe, H. Kitagishi, K. Kano, S. Inokuchi

“Supramolecular Ferric Porphyrins and a Cyclodextrin Dimer as Antidotes for Cyanide Poisoning”

Human and Experimental Toxicology, 33, 360–368 (2014).

(DOI: 10.1177/0960327113499041)
H. Kitagishi, K. Minami, K. Kano

“Intracellular Delivery of Anionic meso-Tetraphenylporphyrin–Per-O-methylated β-Cyclodextrin Supramolecular Complex by an Oligoarginine Carrier Peptide”

Chemistry Letters, 43, 1095–1097 (2014).

(DOI: 10.1246/cl.140298)
H. Kitagishi, S. Hatada, T. Itakura, Y. Maki, Y. Maeda, K. Kano

“Cellular Uptake of Octaarginine-conjugated Tetraarylporphyin Included by Per-O-methylated β-Cyclodextrin”

Organic & Biomolecular Chemistry, 11, 3203–3211 (2013).

(DOI: 10.1039/c3ob27248f)
T. Ueda, S. Kumeda, H. Kitagishi, K. Kano

“Intramolecular Oxidative O-Demethylation in a Per-O-methylated β-Cyclodextrin–Iron Porphyrin Inclusion Complex in Aqueous Solution”

Chemistry Letters, 42, 1366–1368 (2013).

(DOI: 10.1246/cl.130678)
K. Karasugi, H. Kitagishi, K. Kano

“Elongation of Circulation Time of a Diatomic Molecule Receptor in Bloodstream by Attachment to Small Gold Nanoparticles”

Chemistry Letters, 42, 115–117 (2013).

(DOI: 10.1246/cl.2013.115)
K. Watanabe, H. Kitagishi, K. Kano

“Supramolecular Iron Porphyrin/Cyclodextrin Dimer Complex that Mimics the Functions of Hemoglobin and Methemoglobin”

Angewandte Chemie International Edition, 52, 6894–6897 (2013).

(DOI: 10.1002/anie.201302470)
Y. Kakikura, A. Onoda, E. Kubo, H. Kitagishi, T. Uematsu, S. Kuwabata, T. Hayashi

“Supramolecular Linear Assemblies of Cytochrome b562 Immobilized on a Gold Electrode”

Journal of Inorganic and Organometallic Polymers and Materials, 23, 172–179 (2013).

(DOI:10.1007/s10904-012-9737-1)
T. Ueda, H. Kitagishi, K. Kano

“PEGylation of an Artificial O2 and CO Receptor: Synthesis, Characterisation and Pharmacokinetic Study”

Organic & Biomolecular Chemistry, 10, 4337–4347 (2012).

(DOI: 10.1039/c2ob07044h)
K. Kano, S. Chimoto, M. Tamaki, Y. Itoh, H. Kitagishi

“Supramolecular Dioxygen Receptors Composed of an Anionic Water-soluble Porphinatoiron(II) and Cyclodextrin Dimers”

Dalton Transactions, 41, 453–461 (2012).

(DOI: 10.1039/c1dt11596k)
H. Kitagishi, K. Kashiwa, K. Kano

“Functionalization of a Protein Surface with Per-O-Methylated β-Cyclodextrin”

Biopolymers, 97, 11–20 (2012).

(DOI: 10.1002/bip.21695)
J.-K. Rhee, M. Baksh, C. Nycholat, J. C. Paulson, H. Kitagishi, M. G. Finn

“Glycan-Targeted Virus-like Nanoparticles for Photodynamic Therapy”

Biomacromolecules, 13, 2333–2338 (2012).

(DOI: 10.1021/bm300578p)
K. Karasugi, H. Kitagishi, K. Kano

“Modification of a Dioxygen Carrier, HemoCD, with PEGylated Dendrons for Extension of Circulation Time in the Bloodstream”

Bioconjugate Chemistry, 23, 2365–2376 (2012).

(DOI:10.1021/bc300303z)
Y. Sano, A. Onoda, R. Sakurai, H. Kitagishi, T. Hayashi

“Preparation and Reactivity of a Tetranuclear Fe(II) Core in the Metallothionein α-domain”

Journal of Inorganic Biochemistry, 105, 702–708 (2011).

(DOI: 10.1016/j.jinorgbio.2011.01.011)
K. Kano, M. Kondo, H. Inoue, H. Kitagishi, B. Colasson, O. Reinaud

“Calorimetric Study on Coordination of Tridentate Imidazolyl Calix[6]arene Ligand to Zinc Ion in Organic Solvents”

Inorganic Chemistry, 50, 6353–6360 (2011).

(DOI: 10.1021/ic200809k)
K. Oohora, A. Onoda, H. Kitagishi, H. Yamaguchi, A. Harada, T. Hayashi

“A Chemically-Controlled Supramolecular Protein Polymer Formed by a Myoglobin-Based Self-Assembly Systems”

Chemical Science, 2, 1033–1038 (2011).

(DOI: 10.1039/c1sc00084e)
K. Kano, T. Ochi, S. Okunaka, Y. Ota, K. Karasugi, T. Ueda, H. Kitagishi

“Preparation and Function of Poly(acrylic acid)s Modified by Supramolecular Complex Composed of Porphinatoiron and a Cyclodextrin Dimer That Bind Diatomic Molecules (O2 and CO) in Aqueous Solution”

Chemistry –An Asian Journal, 6, 2946–2955 (2011).

(DOI: 10.1002/asia.201100354)
K. Karasugi, H. Kitagishi, K. Kano

“Gold Nanoparticles Carrying Diatomic Molecules (O2 and CO) in Aqueous Solution”

Chemistry –An Asian Journal, 6, 825–833 (2011).

(DOI: 10.1002/asia.201000756)
J.-K. Rhee, M. Hovlid, J. D. Fiedler, S. D. Brown, F. Manzenrieder, H. Kitagishi, C. Nycholat, J. C. Paulson, M. G. Finn

“Colorful Virus-like Particles: Fluorescent Protein Packaging by the Qβ Capsid”

Biomacromolecules, 12, 3977–3981 (2011).

(DOI: 10.1021/bm200983k)
K. Watanabe, H. Kitagishi, K. Kano

“Supramolecular Ferric Porphyrins as Cyanide Receptors in Aqueous Solution”

ACS Medicinal Chemistry Letters, 2, 943–947 (2011).

(DOI: 10.1021/ml200231x)
S. Hirota, N. Tanaka, I. Micetic, P. Di Muro, S. Nagao, H. Kitagishi, K. Kano, R. S. Magliozzo, J. Peisach, M. Beltramini, L. Bubacco

“Structural basis of the lactate-dependent allosteric regulation of oxygen binding in arthropod hemocyanin”

The Journal of Biological Chemistry, 285, 19338–19345 (2010).

(DOI: 10.1074/jbc.M109.076067)
H. Kitagishi, M. Tamaki, T. Ueda, S. Hirota, T. Ohta, Y. Naruta, K. Kano

“Oxoferryl Porphyrin/Hydrogen Peroxide System Whose Behavior is Equivalent to Hydroperoxoferric Porphyrin”

Journal of the American Chemical Society, 132, 16730–16732 (2010).

(DOI: 10.1021/ja106798a)
H. Kitagishi, S. Negi, A. Kiriyama, A. Honbo, Y. Sugiura, A. T. Kawaguchi, K. Kano

“A Diatomic Molecule Receptor That Removes CO in a Living Organism”

Angewandte Chemie International Edition, 49, 1312–1315 (2010).

(DOI: 10.1002/anie.200906149)
H. Kitagishi, K. Kano

“Completely Synthetic Compounds That Bind Diatomic Molecules (O2, CO, NO) in Aqueous Solution”

Jinko Ketsueki, 17, 160–168 (2010) (written in Japanese).
H. Kitagishi, K. Oohora, T. Hayashi

“Thermodynamically Controlled Supramolecular Polymerization of Cytochrome b562”

Biopolymers, 91, 194–200 (2009).

(DOI: 10.1002/bip.21114)
K. Kano, H. Kitagishi

“HemoCD as an Artificial Oxygen Carrier: Oxygen Binding and Autoxidation”

Artificial Organs, 33, 177–182 (2009).

(DOI: 10.1111/j.1525-1594.2008.00704.x)
H. Kitagishi, Y. Kakikura, H. Yamaguchi, K. Oohora, A. Harada, T. Hayashi

“Self-Assembly of One- and Two-Dimensional Hemoprotein Systems by Polymerization through Heme–Heme Pocket Interactions”

Angewandte Chemie International Edition, 48, 1271–1274 (2009).

(DOI: 10.1002/anie.200804006)
K. Kano, Y. Itoh, H. Kitagishi, T. Hayashi, S. Hirota

“A Supramolecular Receptor of Diatomic Molecule (O2, CO, NO) in Aqueous Solution”

Journal of the American Chemical Society, 130, 8006–8015 (2008).

(DOI: 10.1021/ja8009583)
H. Kitagishi, K. Oohora, H. Yamaguchi, H. Sato, T. Matsuo, A. Harada, T. Hayashi

“Supramolecular Hemoprotein Linear Assembly by Successive Interprotein Heme–Heme Pocket Interactions”

Journal of the American Chemical Society, 129, 10326–10327 (2007).

(DOI: 10.1021/ja073295q)
K. Kano, H. Kitagishi, S. Tanaka

“Characterization of an Inclusion Complex of 5,10,15,20-Tetrakis(4-sulfonatophenyl)- porphinato Iron and an O-Methylated β-Cyclodextrin Dimer Having a Pyridine Linker and Its Related Complexes in Aqueous Solution”

Journal of Inclusion Phenomena and Macrocyclic Chemistry, 56, 69–74 (2006).

(DOI: 10.1007/s10847-006-9063-8)
K. Kano, H. Kitagishi, C. Dagallier, M. Kodera, T. Matsuo, T. Hayashi, Y. Hisaeda, S. Hirota

“Iron porphyrin–cyclodextrin supramolecular complex as a functional model of myoglobin in aqueous solution”

Inorganic Chemistry 45, 4448–4460 (2006).

(DOI: 10.1021/ic060137b)
K. Kano, H. Kitagishi, Y. Sone, N. Nakazawa, M. Kodera

“Redox Behavior of a Manganese Porphyrin Complexed with Per-O-methylated β-Cyclodextrin in Aqueous Solution”

European Journal of Inorganic Chemistry, 2006, 4043–4053 (2006).

(DOI: 10.1002/ejic.200600336)
K. Kano, H. Kitagishi, T. Mabuchi, M. Kodera, S, Hirota

“A Myoglobin Functional Model Composed of a Ferrous Porphyrin and a Cyclodextrin Dimer with an Imidazole Linker”

Chemistry –An Asian Journal, 1, 358–366 (2006).

(DOI: 10.1002/asia.200600070)
K. Kano, H. Kitagishi, M. Kodera, S. Hirota

“Dioxygen Binding to a Simple Myoglobin Model in Aqueous Solution”

Angewandte Chemie International Edition, 44, 435–438 (2005).

(DOI: 10.1002/anie.200461609)
K. Kano, H. Kitagishi, S. Tamura, A. Yamada

“Anion Binding to a Ferric Porphyrin Complexed with Per-O-methylated β-Cyclodextrin in Aqueous Solution”

Journal of the American Chemical Society, 126, 15202–15210 (2004).

(DOI: 10.1021/ja045472i)
K. Kano, Y. Horiki, T. Mabuchi, H. Kitagishi

“Heptakis(2,3-di-O-carboxymethyl)-β-cyclodextrin as a pH-sensitive Host”

Chemsitry Letters, 33, 1086–1087 (2004).

(DOI: 10.1246/cl.2004.1086)
H. Kitagishi, A. Satake, Y. Kobuke

“Dynamic Structural Change of a Twisted Hexaporphyrin Complex by Highly Specific Molecular Recognition”

Inorganic Chemistry, 43, 3394–3405 (2004).

(DOI: 10.1021/ic049645g)