このページでは,北岸が2008年に同志社大学に奉職して以来の機能有機化学研究室における論文業績を掲載します。
加納航治先生(Dr. K. Kano)および 北岸個人(Dr. H. Kitagishi)の研究業績は、それぞれのリンクでご覧いただけます。

論文発表

 

2024年

2023年

  1. M. Noguchi, Q. Mao, A. Nakagami, H. Kitagishi
    “Spontaneous reduction of iron(iii)porphyrin to iron(ii)porphyrin–CO complex in mouse circulation”
    Chemical Communications, 59, 6211–6214 (2023)
    https://pubs.rsc.org/en/content/articlelanding/2023/cc/d3cc00420a

  2. S. Mohan, L.-A. Barel, D. E. Benrahla, B. Do, Q. Mao, H. Kitagishi, M. Rivard, R. Motterlini, R. Foresti
    “Development of carbon monoxide-releasing molecules conjugated to polysaccharides (glyco-CORMs) for delivering CO during obesity”
    Pharmacological Research, 191, 106770 (2023)
    (DOI: https://doi.org/10.1016/j.phrs.2023.106770)

  3. Q. Mao, H. Kitagishi
    “Inclusion Complex Formation with Tetra-PEGylated Tetraphenylporphyrin and Face-to-Face Cyclodextrin Dimer through Unprecedented Molecular Threading”
    Chemistry–A European Journal, e202300408 (2023)
    (DOI: https://doi.org/10.1002/chem.202300408)

  4. Q. Mao, X. Zhao, A. Kiriyama, S. Negi, Y. Fukuda, H. Yoshioka, A. T. Kawaguchi, R. Motterlini, R. Foresti, H. Kitagishi
    “A synthetic porphyrin as an effective dual antidote against carbon monoxide and cyanide poisoning”
    Proceedings of the National Academy of Sciences, 120, e2209924120 (2023)
    (DOI: 10.1073/pnas.2209924120 )

  5. S. Negi, M. Hamori, Y. Kawahara-Nakagawa, M. Mashimo, M. Imanishi, N. Kuki, Y. Kawahito, T. Manabe, N. Kawamura, J. Yasukawa, H. Kitagishi, Y. Sugiura
    “Effect of Charged-cluster Distribution of the ZIF268 Zinc Finger Surface on Cell Membrane Permeability”
    Chemistry Letters, 52, 75–78 (2023)
    (DOI: https://doi.org/10.1246/cl.220464)

  6. S. Negi, M. Hamori, Y. Kubo, H. Kitagishi, K. Kano
    “Monolayer formation and chiral recognition of binaphthyl amphiphiles at the air–water interface”
    Bulletin of the Chemical Society of Japan, 96, 48–56 (2023)
    (DOI: 10.1246/bcsj.20220286)

2022年

  1. S. Negi, M. Hamori, H. Kitagishi, K. Kano
    “Highly Ordered Monolayers of an Optically Active Amphiphilic Pyrene Derivative at the Air–Water Interface”
    Bulletin of the Chemical Society of Japan, 95, 1537–1545 (2022)
    (DOI: 10.1246/bcsj.20220233)

  2. M. Tang, Y.-H. Liu, H. Liu, Q. Mao, Q. Yu, H. Kitagishi, Y.-M. Zhang, L. Xiao, Yu Liu
    “Supramolecular Dual Polypeptides Induced Tubulin Aggregation for Synergistic Cancer Theranostics”
    Journal of Medicinal Chemistry, 65, 13473-13481 (2022)
    (DOI: 10.1021/acs.jmedchem.2c01398)

  3. H. Kitagishi, I. Sagami
    “Role of CO in Circadian Clock”
    In Carbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential, (Chapter 5, pp 97–107, 2022)
    (DOI: https://doi.org/10.1002/9781119783435.ch5)

  4. S. Negi, M. Hamori, A. Sato, K. Shimizu, Y. Kawahara-Nakagawa, T. Manabe, N. Shibata, H. Kitagishi, M. Mashimo, Y. Sugiura
    “Transpeptidation Reaction Mediated by Ligand- and Metal Cofactor-Substituted Sortase A from Staphylococcus aureus”
    Bulletin of the Chemical Society of Japan, 95, 1025–1031 (2022)
    (DOI: 10.1246/bcsj.20220098)

  5. S. Negi, M. Hamori, Y. Kawahara-Nakagawa, M. Imanishi, M. Kurehara, C. Kitada, Y. Kawahito, K. Kishi, T. Manabe, N. Kawamura, H. Kitagishi, M. Mashimo, N. Shibata, Y. Sugiura
    “Importance of two-dimensional cation clusters induced by protein folding in intrinsic intracellular membrane permeability”
    RSC Chemical Biology, 3, 1076–1084 (2022)
    https://pubs.rsc.org/en/content/articlehtml/2022/cb/d2cb00098a

  6. R. Tachikawa, H. Saito, H. Moteki, M. Kimura, H. Kitagishi, F. Arce Jr., G. L. See, T. Tanikawa, Y. Inoue
    “Preparation, Characterization, and In Vitro Evaluation of Inclusion Complexes Formed between S-Allylcycteine and Cyclodextrin”
    ACS Omega, 7, 31233–31245 (2022)
    (DOI: 10.1021/acsomega.2c03489)

  7. T. Nagasaki, H. Maeda, K. Taguchi, H. Yanagisawa, K. Nishida, K. Kobayashi, N. Wada, I.Noguchi, R. Murata, H. Sakai, H. Kitagishi,J. Saruwatari, H. Watanabe,M. Otagiri, T. Maruyama
    “A Bioinspired Carbon Monoxide Delivery System Prevents Acute Kidney Injury and the Progression to Chronic Kidney Disease”
    Redox Biology, 54, 102371 (16 pages) (2022)
    (DOI: 10.1016/j.redox.2022.102371)

2021年

  1. H. Kitagishi, Q. Mao
    “Capture of carbon monoxide using a heme protein model: from biomimetic chemistry of heme proteins to physiological and therapeutic applications”
    Polymer Journal, 54, 465-472 (2022)
    (DOI: 10.1038/s41428-021-00591-y)

  2. A. Nakagami, Q. Mao, G. Gouhier, H. Arima, H. Kitagishi
    “FRET-Based In-Cell Detection of Highly Selective Supramolecular Complexes of meso-Tetraarylporphyrin with Peptide/BODIPY-modified Per-O-methyl-β-cyclodextrins”
    ChemBioChem, 16, 3190-3198 (2021).
    (DOI: 10.1002/cbic.202100380)

  3. Q. Mao, P. K. Das, S. Le Gac, B. Boitrel, V. Dorcet, K. Oohora, T. Hayashi, H. Kitagishi
    “Functional Myoglobin Model Composed of a Strapped Porphyrin/Cyclodextrin Supramolecular Complex with an Overhanging COOH That Increases O2/CO Binding Selectivity in Aqueous Solution”
    Inorganic Chemistry, 60, 12392–12404 (2021).
    (DOI: 10.1021/acs.inorgchem.1c01628)

  4. Q. Mao, A. T. Kawaguchi, S. Mizobata, R. Motterlini, R. Foresti, H. Kitagishi
    “Sensitive quantification of carbon monoxide (CO) in vivo reveals a protective role of circulating hemoglobin in CO intoxication”
    Communications Biology, 4, 425 (2021) (15 pages)
    https://www.nature.com/articles/s42003-021-01880-1

  5. H. Kitagishi, K. Kano
    “Synthetic heme protein models that function in aqueous solution”
    Chemical Communications, 57, 148–173 (2021).
    (DOI: 10.1039/D0CC07044K)

2020年

  1. H. Kitagishi, M. Jiromaru, N. Hasegawa
    “Intracellular Delivery of Adamantane-tagged Small Molecule, Proteins, and Liposomes Using an Octaarginine-conjugated β-Cyclodextrin”
    ACS Applied Bio Materials, 3, 4902–4911 (2020).
    (DOI: 10.1021/acsabm.0c00421)

  2. K. Ueno, J. Morstein, K. Ofusa, S. Naganos, E. Suzuki-Sawano, S. Minegishi, S. P. Rezgui, H. Kitagishi, B. W. Michel, C. J. Chang, J. Horiuchi, M. Saitoe
    “Carbon Monoxide, a Retrograde Messenger Generated in Postsynaptic Mushroom Body Neurons, Evokes Noncanonical Dopamin Release”
    Journal of Neuroscience, 40, 3533–3548 (2020).
    (DOI: 10.1523/JNEUROSCI.2378-19.2020)

  3. R. Nishiyabu, Y. Takahashi, T. Yabuki, S. Gommori, Y. Yamamoto, H. Kitagishi, Y. Kubo
    “Boronate Sol-Gel Method for One-Step Fabrication of Polyvinyl Alcohol Hydrogel Coating by Simple Cast- and Dip-Coating Techniques”
    RSC Advances, 10, 86–94 (2020).
    (DOI: 10.1039/C9RA08208E)

2019年

  1. M. Vonesch, J. A. Wytko, H. Kitagishi, K. Kano, J. Weiss
    “Modeling Haemoproteins: Porphyrins and Cyclodextrins as Sources of Inspiration”
    Chemical Communications, 27, 44–52 (2019).
    (DOI: 10.1039/C9CC07545C)

  2. H. Kitagishi
    “In Vivo Reactions Triggered by Selective Removal of Endogenous Carbon Monoxide in Blood Using an Artificial Hemoprotein Model Complex”
    Artificial Blood, 27, 44–52 (2019) (written in Japanese).
    (https://www.blood-sub.jp/kaisinituite.php)

  3. H. Kitagishi, M. Saito, Q. Mao, A. Kiriyama, S. Negi, K. Kano
    “Supramolecular Complexation in Biological Media: NMR Study on Inclusion of an Anionic Tetraarylporphyrin into a Heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin Cavity in Serum, Blood, and Urine”
    Chemistry–An Asian Journal, 14, 3320–3328 (2019).
    (DOI:10.1002/asia.20190983)

  4. H. Kitagishi, K. Ohara, D. Shimoji, M. Vonesch, J. Weiss, J. A. Wytko
    “Hydrogen Bond Directed Molecular Recognition in Water in a Strapped-Porphyrin-Cyclodextrin Assembly”
    Journal of Porphyrins and Phthalocyanines, 23, 569–574 (2019).
    (DOI:10.1142/S1088424619500494)

  5. R. Suzuki, Y. Inoue, I. Murata, H. Nomura, Y. Issiki, M. Hashimoto, Y. Kudo, H. Kitagishi, S. Kondo, I. Kanamoto
    “Preparation, Characterization, and Study of the Antimicrobial Activity of a Hinokitiol-copper(II)/γ-cyclodextrin Ternary Complex”
    Journal of Molecular Structure, 1194, 9–27 (2019).
    (DOI:10.1016/j.molstruc.2019.05.078)

  6. M. Kodera, Y. Kadoya, K. Aso, K. Fukui, A. Nomura, Y. Hitomi, H. Kitagishi
    “Acceleration of Hydrolytic DNA Cleavage by Dicopper(II) Complexes with p-Cresol-Derived Dinulearing Ligands at Slightly Acidic pH and Mechanistic Insights”
    Bulletin of the Chemical Society of Japan, 92, 739–747 (2019).
    (DOI:10.1246/bcsj.20180353)

  7. A. Ollivier, R. Foresti, Z. El Ali, T. Martens, H. Kitagishi, R. Motterlini, M. Rivard
    “Design and Biological Evaluation of Manganese- and Ruthenium-based Hybrid CO-RMs (HYCOs)”
    ChemMedChem, 14, 1684–1691 (2019).
    (DOI:10.1002/cmdc.201900426)

  8. K. Oohora, R. Kajihara, M. Jiromaru, H. Kitagishi, T. Hayashi
    “Arginine Residues Provide a Multivalent Effect for Cellular Uptake of a Hemoprotein Assembly”
    Chemistry Letters, 48, 295–298 (2019).
    (DOI:10.1246/cl.180897)

  9. Q. Mao, H. Kitagishi
    “Optimized Synthesis of a Per-O-methylated β-Cyclodextrin Dimer Linked at the Secondary Face by a Pyridine Ligand”
    Journal of Inclusion Phenomena and Macrocyclic Chemistry, 93, 67–76 (2019).
    (DOI:10.1007/s10847-018-0839-4)

2018年

  1. L. Braud, M. Pini, L. Muchova, S. Manin, H. Kitagishi, D. Sawaki, G. Czibik, J. Ternacle, G. Derumeaux, R. Foresti, R. Motterlini
    “Carbon Monoxide-induced Metabolic Switch in Adipocytes Improves Insulin Resistance in Obese Mice”
    JCI Insight, 3, e123485 (2018).
    (DOI:10.1172/jci.insight.123485)

  2. A. T. Kawaguchi, A. Salybekov, M. Yamano, H. Kitagishi, K. Sekine
    “PEGylated Carboxyhemoglobin Bovine (SANGUINATE) Ameliorates Myocardial Infarction in a Rat Model”
    Artificial Organs, 42, 1174–1184 (2018).
    (DOI:10.1111/aor.13384)

  3. S. Minegishi, I. Sagami, S. Negi, K. Kano, H. Kitagishi
    “Circadian Clock Disruption by Selective Removal of Endogenous Carbon Monoxide”
    Scientific Reports, 8, 11996 (2018).
    (DOI: 10.1038/s41598-018-30425-6)

  4. H. Kitagishi, D. Shimoji, T. Ohta, R. Kamiya, Y. Kudo,
    A. Onoda, T. Hayashi, J. Weiss, J. A. Wytko, K. Kano

    “A Water-Soluble Supramolecular Complex that Mimics the Heme/Copper Hetero-Binuclear Site of Cytochrome c Oxidase”
    Chemical Science, 9, 1989–1995 (2018).
    (DOI: 10.1039/c7sc04732k)

2017年

  1. S. Minegishi, A. Yumura, H. Miyoshi, S. Negi, S. Taketani,
    R. Motterlini, R. Foresti, K. Kano, H. Kitagishi
    “Detection and Removal of Endogenous Carbon Monoxide by Selective and Cell-permeable Hemoprotein-model Complexes”
    Journal of the American Chemical Society, 139, 5984–5991 (2017).
    (DOI: 10.1021/jacs.7b02229)

  2. H. Kitagishi, S. Minegishi
    “Iron(II)porphyrin–Cyclodextrin Supramolecular Complex as a Carbon Monoxide-Depleting Agent in Living Organisms”
    Chemical and Pharmaceutical Bulletin, 65, 336–340 (2017).
    (DOI: 10.1248/cpb.c16-00767)

  3. H. Kitagishi, Y. Sugaya, K. Komazawa, M. Tamaki, K. Kano
    “Participation of Hydroxyl Radical in the Formation of Verdoheme-type Compound in the Reaction of a Ferric Porphyrin with Hydrogen Peroxide”
    Chemistry Letters, 46, 509–512 (2017).
    (DOI: 10.1246/cl.161161)

  4. H. Kitagishi, Q. Mao, N. Kitamura, T. Kita
    “HemoCD as a Totally Synthetic Artificial Oxygen Carrier: Improvements in the Synthesis and O2/CO Discrimination”
    Artificial Organs, 41, 372–380 (2017).
    (DOI: 10.1111/aor.12870)

  5. R. Nishiyabu, S. Iizuka, S. Minegishi, H. Kitagishi, Y. Kubo
    “Surface Modification of a Polyvinyl Alcohol Sponge with Functionalized Boronic Acids to Develop Porous Materials for Multicolor Emission, Chemical Sensing and 3D Cell Culture”
    Chemical Communications, 53, 3563–3566 (2017).
    (DOI: 10.1039/c7cc00490g)

2016年

  1. H. Kitagishi, S. Kurosawa, K. Kano
    “Intramolecular Oxidative O-Demethylation of an Oxoferryl Porphyrin Complexed with a Per-O-methylated β-Cyclodextrin Dimer”
    Chemistry –An Asian Jouranl, 11, 3213–3219 (2016).
    (DOI:10.1002/asia.201601097)

  2. W. Takabe, Y. Urano, D. H. Vo, K. Shibuya, M. Tanno,
    H. Kitagishi, T. Fujimoto, N. Noguchi
    “Esterification of 24S-OHC Induces Formation of Atypical Lipid Droplet-like Structures, Leading to Neuronal Cell Death.
    Journal of Lipid Research, 57, 2005–2014 (2016).
    (DOI: 10.1194/jlr.M068775)

  3. K. Shibuya, T. Watanabe, Y. Urano, W. Takabe, N. Noguchi,
    H. Kitagishi
    “Synthesis of 24(S)-Hydroxycholesterol Esters Responsible for the Induction of Neuronal Cell Death”
    Bioorganic & Medicinal Chemisty, 24, 2559–2566 (2016).
    (DOI: 10.1016/j.bmc.2016.04.024)

  4. H. Kitagishi, S. Minegishi, A. Yumura, S. Negi, S. Taketani,
    Y. Amagase, Y. Mizukawa, T. Urushidani, Y. Sugiura, K. Kano
    “Feedback Response to Selective Depletion of Endogenous Carbon Monoxide in the Blood”
    Journal of the American Chemical Society, 138, 5417–5425 (2016).
    (DOI: 10.1021/jacs.6b02211)

  5. K. Imabeppu, H. Kuwano, E. Yutani, H. Kitagishi, K. Kano
    “Photoinduced Homolysis of Alkyl-Cobalt(III) Bonds in a Cyclodextrin Cage”
    European Journal of Inorganic Chemistry, 1784–1789 (2016).
    (DOI: 10.1002/ejic.201600208)

2015年

  1. H. Kitagishi, H. Kawasaki, K. Kano
    “Bioconjugation of Serum Albumin to a Maleimide-appended Porphyrin/Cyclodextrin Supramolecular Complex as an Artificial Oxygen Carrier in the Bloodstream”
    Chemistry –An Asian Journal, 10, 1768–1775 (2015).
    (DOI: 10.1002/asia.201500451)

  2. K. Watanabe, T. Suzuki, H. Kitagishi, K. Kano
    “Reaction Between a Haemoglobin Model Compound and Hydrosulphide in Aqueous Solution”
    Chemical Communications, 51, 4059–4061 (2015).
    (DOI: 10.1039/C5CC00057B)

  3. H. Kitagishi, F. Chai, S. Negi, Y. Sugiura, K. Kano
    “Supramolecular Intracellular Delivery of an Anionic Porphyrin by Octaarginine-conjugated Per-O-methyl-β-Cyclodextrin”
    Chemical Communications, 51, 2421–2424 (2015).
    (DOI: 10.1039/C4CC09042J)



2014年

  1. T. Ueda, H. Kitagishi, K. Kano
    “Intramolecular Direct Oxygen Transfer from Oxoferryl Porphyrin to a Sulfide Bond”
    Inorganic Chemistry, 53, 543–551 (2014).
    (DOI: 10.1021/ic4026393)


  2. H. Kitagishi, K. Minami, K. Kano
    “Intracellular Delivery of Anionic meso-Tetraphenylporphyrin – Per-O-methylated β-Cyclodextrin Supramolecular Complex by an Oligoarginine Carrier Peptide”
    Chemistry Letters, 43, 1095–1097 (2014).
    (DOI: 10.1246/cl.140298)

2013年

  1. H. Kitagishi, S. Hatada, T. Itakura, Y. Maki, Y. Maeda, K. Kano
    “Cellular Uptake of Octaarginine-conjugated Tetraarylporphyin Included by Per-O-methylated β-Cyclodextrin”
    Organic & Biomolecular Chemistry, 11, 3203–3211 (2013).
    (DOI:
    10.1039/c3ob27248f)

  2. T. Ueda, S. Kumeda, H. Kitagishi, K. Kano
    “Intramolecular Oxidative O-Demethylation in a Per-O-methylated β-Cyclodextrin–Iron Porphyrin Inclusion Complex in Aqueous Solution”
    Chemistry Letters, 42, 1366–1368 (2013).
    (DOI: 10.1246/cl.130678)

  3. K. Karasugi, H. Kitagishi, K. Kano
    “Elongation of Circulation Time of a Diatomic Molecule Receptor in Bloodstream by Attachment to Small Gold Nanoparticles”
    Chemistry Letters, 42, 115–117 (2013).
    (DOI: 10.1246/cl.2013.115)

  4. K. Watanabe, H. Kitagishi, K. Kano
    “Supramolecular Iron Porphyrin/Cyclodextrin Dimer Complex that Mimics the Functions of Hemoglobin and Methemoglobin”
    Angewandte Chemie International Edition, 52, 6894–6897 (2013).
    (DOI: 10.1002/anie.201302470)

2012年

  1. T. Ueda, H. Kitagishi, K. Kano
    “PEGylation of an Artificial O2 and CO Receptor: Synthesis, Characterisation and Pharmacokinetic Study”
    Organic & Biomolecular Chemistry, 10, 4337–4347 (2012).
    (DOI: 10.1039/c2ob07044h)

  2. K. Kano, S. Chimoto, M. Tamaki, Y. Itoh, H. Kitagishi
    “Supramolecular Dioxygen Receptors Composed of an Anionic Water-soluble Porphinatoiron(II) and Cyclodextrin Dimers”
    Dalton Transactions, 41, 453–461 (2012).
    (DOI: 10.1039/c1dt11596k)

  3. H. Kitagishi, K. Kashiwa, K. Kano
    “Functionalization of a Protein Surface with Per-O-Methylated β-Cyclodextrin”
    Biopolymers, 97, 11–20 (2012).
    (DOI: 10.1002/bip.21695)

  4. K. Karasugi, H. Kitagishi, K. Kano
    “Modification of a Dioxygen Carrier, HemoCD, with PEGylated Dendrons for Extension of Circulation Time in the Bloodstream”
    Bioconjugate Chemistry, 23, 2365–2376 (2012).
    (DOI: 10.1021/bc300303z)

2011年

  1. K. Kano, M. Kondo, H. Inoue, H. Kitagishi, B. Colasson, O. Reinaud
    “Calorimetric Study on Coordination of Tridentate Imidazolyl Calix[6]arene Ligand to Zinc Ion in Organic Solvents”
    Inorganic Chemistry, 50, 6353–6360 (2011).
    (DOI: 10.1021/ic200809k)

  2. K. Kano, T. Ochi, S. Okunaka, Y. Ota, K. Karasugi, T. Ueda, H. Kitagishi
    “Preparation and Function of Poly(acrylic acid)s Modified by Supramolecular Complex Composed of Porphinatoiron and a Cyclodextrin Dimer That Bind Diatomic Molecules (O2 and CO) in Aqueous Solution”
    Chemistry –An Asian Journal, 6, 2946–2955 (2011).
    (DOI: 10.1002/asia.201100354)

  3. K. Karasugi, H. Kitagishi, K. Kano
    “Gold Nanoparticles Carrying Diatomic Molecules (O2 and CO) in Aqueous Solution”
    Chemistry –An Asian Journal, 6, 825–833 (2011).
    (DOI: 10.1002/asia.201000756)


  4. K. Watanabe, H. Kitagishi, K. Kano
    “Supramolecular Ferric Porphyrins as Cyanide Receptors in Aqueous Solution”
    ACS Medicinal Chemistry Letters, 2, 943–947 (2011).
    (DOI: 10.1021/ml200231x)

2010年

  1. H. Kitagishi, M. Tamaki, T. Ueda, S. Hirota, T. Ohta, Y. Naruta, K. Kano
    “Oxoferryl Porphyrin/Hydrogen Peroxide System Whose Behavior is Equivalent to Hydroperoxoferric Porphyrin”
    Journal of the American Chemical Society, 132, 16730–16732 (2010)
    (DOI: 10.1021/ja106798a)

  2. H. Kitagishi, S. Negi, A. Kiriyama, A. Honbo, Y. Sugiura, A. T. Kawaguchi, K. Kano
    “A Diatomic Molecule Receptor That Removes CO in a Living Organism”
    Angewandte Chemie International Edition, 49, 1312–1315 (2010)
    (DOI: 10.1002/anie.200906149)

2009年

  1. K. Kano, H. Kitagishi
    “HemoCD as an Artificial Oxygen Carrier: Oxygen Binding and Autoxidation”
    Artificial Organs, 33, 177–182 (2009)
    (DOI: 10.1111/j.1525-1594.2008.00704.x)

2008年

  1. K. Kano, Y. Itoh, H. Kitagishi, T. Hayashi, S. Hirota
    “A Supramolecular Receptor of Diatomic Molecule (O2, CO, NO) in Aqueous Solution”
    Journal of the American Chemical Society, 130, 8006–8015 (2008)
    (DOI: 10.1021/ja8009583)

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